ea0019oc30 | Bone and Calcium | SFEBES2009
Walls G
, Bowl M
, Jeyabalan J
, Reed A
, Harding B
, Ali A
, Bradley K
, Wang P
, Chen J
, Williams B
, Teh B
, Thakker R
The hyperparathyroidism-jaw tumour (HPT-JT) syndrome, an autosomal dominant disorder, is characterised by the occurrence of parathyroid tumours, often carcinomas, and ossifying fibromata of the jaw. The HPT-JT gene, referred to as HRPT2, is located on chromosome 1q25 and consists of 17 exons that encode a 531 amino-acid protein designated parafibromin. To explore the role of HRPT2 in parathyroid tumourigenesis, we generated two mouse models that comprised a conve...